其他信息
| 抗体种属性 | Human |
|---|---|
| Negative species | Pig |
| 克隆号 | MEM-148 |
| 同型对照 | Mouse IgG1 |
| 应用 | FC (QC tested), IP, WB, FUNC |
| 浓度 | 1 mg/ml |
| 保存缓冲液 | Phosphate buffered saline (PBS), pH 7.4 |
| 保存温度 | Store at 2-8°C. Do not freeze. |
| 产品详情链接 |
12-340-C100 | Anti-Hu CD18 Purified Low Endotoxin, 0.1 mg
¥2922.08
CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
