1P-651-C100 | Anti-Notch1 PE, 0.1 mg

¥3237.39

Notch 1 is a 270-300 kDa transmembrane heterodimeric protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands, such as Delta 1, Jagged 1 (CD339), and Jagged 2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates to the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in brain, lung and thymus.

SKU: exbio-1P-651-C100 分类: ,

其他信息

抗体种属性

Mouse, Human

Negative species

Rat

克隆号

mN1A

同型对照

Mouse IgG1 kappa

应用

FC (QC tested)

浓度

0.1 mg/ml

保存缓冲液

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

保存温度

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

产品详情链接

https://exbio.cz/research-product/antibodies/nucleus/anti-notch1-pe