A4-539-C100 | Anti-PSMA Alexa Fluor® 488, 0.1 mg

¥5669.82

Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I), folate hydrolase (FOLH1), and prostate-specific membrane antigen (PSMA), is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate, which is released from neurons in a calcium-dependent manner, to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic, GCPII contributes to pathological conditions regarding e.g. Alzheimer´s disease, Huntington´s disease, epilepsy, schizophrenia, stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate, enabling folate to be absorbed by gastrointestinal tract. GCPII, which is present in a number of tissues at low levels, is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM´) than mRNA for membrane-bound GCPII, and this ratio is reversed upon malignant transformation.

SKU: exbio-A4-539-C100 分类: ,

其他信息

抗体种属性

Human

克隆号

GCP-05

同型对照

Mouse IgG1

应用

FC (QC tested), ICC

浓度

1 mg/ml

保存缓冲液

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

保存温度

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

产品详情链接

https://exbio.cz/research-product/antibodies/cd-and-related-antigens/anti-psma-alexa-fluor-sup-sup-488