A6-269-C100 | Anti-LCK Alexa Fluor® 647, 0.1 mg

¥5189.34

Lck is a Src-family tyrosine kinase, which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, Lck phosphorylates the ITAM motives in its zeta subunits, establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane, there is also a significant fraction associated with the Golgi apparatus, which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors.

SKU: exbio-A6-269-C100 分类: ,

其他信息

抗体种属性

Human

Negative species

Mouse

克隆号

LCK-01

同型对照

Mouse IgG1

应用

FC (QC tested), WB, ICC

浓度

1 mg/ml

保存缓冲液

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

保存温度

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

产品详情链接

https://exbio.cz/research-product/antibodies/other-intracellular-antigens/anti-lck-alexa-fluor-sup-sup-647