A6-822-C100 | Anti-MICA/MICB Alexa Fluor® 647, 0.1 mg

¥5189.34

MICA and MICB glycoproteins are members of MHC class I family, closely linked to HLA-B. However, unlike HLA molecules, MICA and MICB are not associated with beta2 microglobulin and are conformationally stable in the absence of conventional MHC class I peptide ligands. Both proteins are stress-induced antigens expressed mainly in gastrointestinal epithelium, where they are recognized by V-delta1 subset of gamma/delta T cells, and also on diverse epithelial tumor cells. Binding of MICA/MICB receptor, the NKG2D, leads to cytolytic response of NK cells, Tc cells, and gamma/delta T cells. Alternative splicing results in multiple isoforms, and some of them have been associated with susceptibility to psoriasis and psoriatic arthritis. Shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma.

SKU: exbio-A6-822-C100 分类: ,

其他信息

抗体种属性

Human

克隆号

6D4

同型对照

Mouse IgG2a

应用

FC (QC tested)

浓度

0.1 mg/ml

保存缓冲液

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

保存温度

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

产品详情链接

https://exbio.cz/research-product/antibodies/mhc-antigens/anti-mica-micb-alexa-fluor-sup-sup-647